Microbial Transformation of (–)-α-Bisabolol Towards Bioactive Metabolites
نویسندگان
چکیده
منابع مشابه
Microbial technologies for the discovery of novel bioactive metabolites.
Soil microbes represent an important source of biologically active compounds. These molecules present original and unexpected structure and are selective inhibitors of their molecular targets. At Biosearch Italia, discovery of new bioactive molecules is mostly carried out through the exploitation of a proprietary strain collection of over 50000 strains, mostly unusual genera of actinomycetes an...
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1Department of Biotechnology and Life Sciences, University of Insubria andThe Protein Factory, Interuniversity Centre Politecnico di Milano, ICRM CNR Milano and University of Insubria, Varese, Italy 2Fundación MEDINA, Health Sciences Technology Park, Granada, Spain 3Department of Genetics and Biotechnology, Ivan Franko National University of Lviv, Ukraine 4Department of Molecular Microbiology a...
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Microbial transformation of the anti-inflammatory steroid medrysone (1) was carried out for the first time with the filamentous fungi Cunninghamella blakesleeana (ATCC 8688a), Neurospora crassa (ATCC 18419), and Rhizopus stolonifer (TSY 0471). The objective was to evaluate the anti-inflammatory potential of the substrate (1) and its metabolites. This yielded seven new metabolites, 14α-hydroxy-6...
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Mycobacterium smegmatis PTCC 1307 (CIP 73.26) was used as a microbial agent to produce androsta-1,4-diene-3,17-dione (ADD) and androst-4-ene-3,17-dione, two useful precursors in the synthesis of steroid drugs. The side chain of cholesterol, as the substrate, was selectively cleaved in the presence of five enzyme inhibitors. An intermediate structure with intact side chain, cholest-4-ene-3-one, ...
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Recent results in the chemistry of bioactive marine products are presented. Concerning the cytotoxic a-carbolines : grossularins A and B, the mechanism of the toxicity using supercoiled DNA and synthesis of the imidazolo-a-carboline moiety are presented. In the polysulfur compounds series, the structure of lissoclinotoxin B is proposed as well as a new synthesis of pentathiepins. Novel sesquite...
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ژورنال
عنوان ژورنال: Records of Natural Products
سال: 2021
ISSN: 1307-6167
DOI: 10.25135/rnp.252.2004.1615